44 room inn, each room unique with antiques. Lovely living room and dining area for lounging. Serves continental breakfast. Staff is friendly and make you feel at home - very accommodating. Inn is located in the heart of Portsmouth and is rated 4-1/2 stars. You can walk to view local historic sites. No children allowed. We would definitely return -... more

I'm originally from Portsmouth, so I've never stayed at a hotel there. I wanted to be somewhere that felt like staying with old friends and this place is it! The innkeeper and her staff are excellent! Truly like friends instead of just employees. I spent hours chatting with them at all hours. The location is perfect for walking around downtown,... more

We stayed in the Sise Inn for one night on our recent road trip through New England. Portsmouth is a truly beautiful town. Its buildings are old and grand, its homes are beautiful and the harbour picturesque. The Sise Inn is a sort of hybrid B&B: set in a very large, very grand old home within walking distance to everywhere... more

The Sise Inn was a very pleasent place to stay, two minor oddities were the sink in an alcove outside the main bathroom and the fairly noisy bed which creaked like mad even if you turned over during the night. Minor points only, the Inn itself is nicely decorated and the staff were very nice, parking was more than adequate... more

This was a really nice inn/B & B to stay in during our trip to Portsmouth. The front desk was awesome, so helpful and friendly! Our room was huge! The bathroom was split between the shower/toilet and the sink/clothing rack. It was a great design, not usually seen in hotels. We thoroughly enjoyed our stay. The hotel was clean and... more

My husband and I had a very nice stay at the Sise Inn this past winter. The rooms are cozy and clean and the staff is pleasant. It's not quite a hotel, not quite a b&b, so you get the charm and homey feel of a b&b, but the privacy and continental breakfast of a hotel (the continental breakfast was... more

My fiance and I did a weekend overnight in Portsmouth and stayed at the Sise Inn. It was our first stay, and we were pleasantly suprised. We stayed in the Carriage House, which is separate from the main inn, but just a few steps from the entrance. We had a jacuzzi tub and sauna in our room. It was older,... more

My wife and I have been staying at The Sise Inn for almost 10 years, including more than 15 stays. We have invariably had great service, a great room, and a wonderful time. And now with our active preschooler, the Inn has been a great place for families, too. The rooms vary in size, from simple studio layouts, to larger... more

Although we only live an hour away, we stayed there during a snowstorm 14 years ago and returned on a recent Saturday night after attending a holiday concert in Portsmouth and not wanting to drive home that night. I had not read the Trip Advisor reviews until after our stay and quite frankly I was surprised to read the many... more