Sounds like a lovely trip. Don't forget that when you're in San Fran you're also very close to the NAPA Valley and its vineyards and wineries.
Either Morro Bay or San Luis Obispo is probably the logical place to stop on your way south. If you map it out you'll see that it's 248 miles with an estimate of 5 hours, but with the views and sites along the way you'll take longer, so get an early start.
After a good rest I would suggest a round about way to Santa Barbara that will give you some of the best mountain roads and views in Southern California. Just north of Santa Maria take route 166 East to route 33 south. This will bring you in to an adorable little town called Ojai. Depending on your arrival, this is a wonderful town to enjoy breakfast or lunch. After Ojai, follow route 150 West (another amazingly scenic route) past Lake Casitas to route 101 and follow it north to Santa Barbara. I ride these roads often and never tire of them.
Near Santa Barbara is an area called the Santa Ynez valley and is home to many wonderful wine makers and golf courses. That area was featured in the film "Sideways."
As you come south towards LA, take the PCH (Pacific Coast Highway) through Malibu and Santa Monica, but bring your patience and expect traffic. FYI: Just south of Santa Monica is the famous Venice Beach.
*Personal opinion: Above Malibu, Santa Monica and Venice I prefer Hermosa Beach for the penultimate California beach experience. Santa Monica is too crowded and Venice has too many dodgy characters.
GOLF: Check out the courses near Griffith Park in Los Angeles. Nice courses and near everything. While he's golfing there you can shoot over to the Americana mall in Glendale (google it), just about 5 miles away and easy to get to or go to the Griffith Park observatory for the best views of LA. (FREE!!)
*Another great free activity, you can watch polo matches for free at Will Rogers State park in Pacific Palisades...but you do have to pay for parking.
Edited: 22 May 2012, 21:16