I stayed here for Friday and Saturday nights while visiting a friend and her family in Brookline. I can't speak to the convenience of the inn to Boston, because I didn't do any site seeing there. But the inn itself is very cozy. I had one of the rooms on the top floor. The bed was comfortable, and the decoration was not too frou frou or cutesy (although also definitely far from trendy or hip). The bathroom was only adequate -- basically the size of a small powder room, with a fiberglass shower stall, but clean and serviceable. The toiletries weren't anything too fancy. The breakfast was tasty and ample, and snacks were available at other times. This wasn' t the most luxurious place I've ever stayed, but it was very good for the price. The service was also very helpful and pleasant.

Possible downsides. It might be tough for disabled or older people (not sure how they would get up and down all the steps). Finally, this didn't strike me as the most "romantic" of bed and breakfasts -- there weren't a lot of couples on a romantic trip, but rather some families with college-age children, a couple with a baby who was house hunting, a pair of women who were touring Boston.

This is a great place to stay when visiting the Boston area. It's well run, beautifully appointed, quiet, accommodating and comfortable. Reasonable prices too. Wonderful attention to guests ensures that I will always recommend and come back to stay.

The Inn is well located for getting the underground into Boston. There are good restaurants within walking distance so a car is not needed. You can get all the way to the INN from the airport on the underground, but there is one change needed.
The room was well presented, clean and comfortable. Breakfast was taken in the entrance hall where there were only three small tables! So many guests just took their breakfast back to their rooms.
The breakfasts were not much to talk about. When we asked one day if there was any boiled eggs, they brought out from the fridge yesterdays left over boiled eggs, cold and unappetising.
Tea, coffe and biscuits available all day in the entrance hall. There was no lounge in which to relax. The sister hotel Bertrams Inn, just across the road did have a lounge so this may be a better place to stay, but still no proper breakfast room.

Found this place online and read all the great reviews on Trip Advisor, so decided to give it a try. When all the halfway respectable hotels were going for $400-$500 a night, The Samuel Sewall was half that with just as much (and in some cases twice as much) character. Absolutely charming, the rooms are beautiful and very comfortable; ours even had a fireplace (although we didn't have a chance to light it). The staff is friendly and helpful, the location is convenient to the train (and hence downtown) and is only a short walk to several nice restaurant and to Fenway Park. Would definitely stay there again!