Saskatoon's neighbourhoods are as diverse as the people who live in them.

The Central Business District is Saskatoon's downtown on the west bank of the South Saskatchewan River.  The area first developed around 1890 when the railway was laid down, and consisted largely of commerical facilities.  In 1901, the settlement incorporated as the village of Saskatoon, becoming a town only two years later.  In 1906, Saskatoon merged with the adjacent settlements of Riversdale and Nutana to incoporate as the city of Saskatoon.  The downtown area remains to this day the heart of activity and major events in the city.  The landmark Bessborough Hotel , the last of Canada's grand railway hotels, opened in 1935.  Major redevelopment occurred in the 1960s when the Canadian National (CN) rail lines were relocated.  The Midtown Plaza , Saskatoon's largest enclosed shopping mall, opened in 1970 on the site of the former railway station.  A renovation in the 1990s saw the facade of the mall altered to mimic the original train station.  TCU Place (formerly Centennial Auditorium), a 2000 seat performing arts theatre, opened in 1968.  It is home to the Saskatoon Symphony Orchestra and hosts a number of concerts and conventions.  Under construction in 2006 is the River Landing development in the south downtown.  Included in these ambitious plans is a hotel and spa, riverbank park, and a new home for Persephone Theatre , Saskatoon's most prestigious professional theatre company.

Nutana is directly across from downtown on the east bank of the river.  It is bounded by the river to the north and west, 8th Street to the south and Clarence Avenue to the east.  Originally a temperance colony founded in 1883 by John Lake and the Toronto Methodists, its original name was Saskatoon.  When the west bank settlement (present day downtown) incorporated and took the name Saskatoon, the east bank settlement renamed itself Nutana.  It remained a separate community until 1906, when it merged with Saskatoon and Riversdale.  At the heart of this neighbourhood is Broadway Avenue , the main commercial zone.  Filled with interesting shops, restaurants and bars, Broadway is also a magnet for the artistic community.  The street is closed periodically during the summer for festivals, most notably the Saskatoon International Fringe Festival . The historic Broadway Theatre , a 1940s art deco gem, is the city's only independent cinema as well as a venue for live entertainment.

Riversdale is directly west of downtown, centered around 20th Street.  The first settlements appeared in 1903, and by 1905 the village of Riversdale was incorporated.  Only a year later, the village merged with nearby Saskatoon and Nutana to form the city of Saskatoon.  Today the neighbourhood is home to a large First Nations population.  While parts of this community struggle with poverty, addiction and crime, there many success stories as well.  The historic Roxy Theatre , first opened in 1930, was restored and re-opened in 2005 after a ten year closure.  The Saskatoon Farmers Market operates at Avenue B and 19th Street, offering local agricultural products, baking, prepared foods and crafts. Considerable effort is being put into creating a "cultural corridor" linking Riversdale to the new River Landing development and the Broadway district.

The Mayfair neighbourhood is one of the oldest in Saskatoon outside of the original three settlements of Nutana, Saskatoon and Riversdale.  It remained in private hands until 1911, when the expanding city of Saskatoon annexed the land.  The area received a school in 1921 and development continued well into the 1960s.  Today, Mayfair is an established, working-class neighbourhood of about 2500 people.  Activity in Mayfair remains centered along 33rd Street, where many interesting shops and restaurants can be found.  One revered institution is Christie’s Mayfair Bakery , established in 1933 and widely regarded as the city's finest bakery.

Sutherland is located east of Circle Drive and north of College Avenue, straddling the tracks of the Canadian Pacific Railway.  It begin its life as a community separate from Saskatoon; it was incorporated as a village in 1909 and again as a town in 1912.  By 1956, Saskatoon had grown so much that the town was annexed and incorporated into the city.  Central Avenue, the former town's main street, remains an important commercial avenue to this day.

Silverspring is a primarily residential neighbourhood in the northeast with a couple of distinguishing features.  Within its boundaries is an area of natural prairie grassland that will not be developed.  Native plant and animal life can be viewed while walking through the area on gravel trails.  Adjacent to it is the former Sutherland Forest Nursery Station established by the federal Department of the Interior in 1913.  After the nursery was closed in the mid 1960s, the city took over the property and established the Saskatoon Forestry Farm Park and Zoo.   Spacious green lawns, flower gardens, sport fields, heritage landmarks and the zoo make this place a favourite site for all people of all ages and interests.