The architecture in Karachi ranges from Victorian buildings dating to the colonial era, Hindu-inspired buildings that predate the formation of Pakistan, and modern structures (mainly apartment complexes, highrises and hotels).

The general architecture of the city is low (between two and four stories), though taller buildings are now becoming commonplace in densely populated regions. Various large thoroughfares throughout the city have massive flyovers and underpasses constructed amidst old and new buildings alike. Huge billboards atop buildings also affect the cityscape. The vast majority of the city sprawl is dominated by residential areas that range from ultra modern communities to shanty towns and slums.

The older parts of the city center such as Old Clifton, Saddar, I.I. Chundrigar Road and Mohammad Ali Jinnah Road contain striking examples of colonial era architecture dating to the 1800s in some cases. Of note are the Customs Building near Karachi Port, Mereweather Clock Tower, Governor House, The Karachi High Court, Frere Hall, Hindu Gymkhana (now NAPA, the National Academy of Performing Arts), and Mohatta Palace, the latter two being strongly influenced by Hindu architecture.

Newer buildings of interest include the Habib Bank Tower, MCB Tower, and several hotels such as the Avari Towers, Pearl Continental Hotel and the Avari Towers. There are also several mosques which have unique characteristics, such as the Tooba Mosque in Defence which has the largest (diameter) dome in the world.

Exploring Defence Housing Authority will also result in some surprising discoveries for the architectural enthusiast, but be warned! some of the houses in this posh neighbourhood are downright grotesque.