Visitors can fly into Lafayette Regional Airport from most major U.S. cities with a variety of major carriers. However, instead of taking nonstop flights, many will find themselves landing in other southern cities and then transferring planes to Lafayette. http://www.lftairport.com/  . 
     For people who prefer to travel by train, the city of Lafayette is served by Amtrak - visitors will primarly end up passing through New Orleans if they come in from the east, and through Houston and Beaumont, Texas if they come in from the West.
     Finally, it is also possible and fairly easy to reach Lafayette by Greyhound bus given the city's proximity to a major interstate.
     For those coming to the city by car, Lafayette is as simple as driving in on Route I-10, the same interstate that goes all the way across the U.S. between Northern Florida and the far South of California, not to mention New Orleans, which is about a two hour drive from the Southeast on I-10.  Visitors driving to Lafayette from New Orleans may also want to consider skipping the Interstate and taking some of the slower backroads so that they can get a better look at the cajun country, landscape and attractions that can be found in this colorful region.  As one of the larger cities in Louisiana, car rentals will be easy and widely available here as well.