Philadelphia International Airport is the largest airport in the Delaware Valley region, and the most convenient to fly into if you want to get to West Chester. The airport is a major hub for US Airways, which operates all of Terminal F as well as Concourses B and C. You can get to Philadelphia from most major cities via this airline, and there are even some international flights from Canada, the Caribbean and Europe.

Another good way to get into Philadelphia is via train, since the city was formerly a major hub for several major rail companies. The railroad station on 30th Street is a junction for Amtrak. There are north-south services to cities along the Eastern seaboard from Boston to Miami. Trains also run westward to Chicago, Pittsburgh and New Orleans.

If you wish to drive to West Chester yourself, the borough is located on West Chester Pike (Pennsylvania Route 3) 25 miles west of Philadelphia. The route begins in Upper Darby, just west of Philadelphia proper; the West Chester exit is at E Gay Street. The borough is also quite close to Wilmington, Delaware, which lies only 17 miles to the south. To get to West Chester from Delaware, take the Concord Pike out of Wilmington and continue on Wilmington Pike until you get to W Gay Street. If you are coming from farther away, take Route 76 (the Pennsylvania Turnpike) or Interstate 95 to get into the Philadelphia region.