The Greenville-Spartanburg International Airport (GSP) is just fifteen miles from downtown Greenville.

The Greenville Downtown Airport (GMU) is located in Greenville's business district.  GMU is South Carolina's busiest general aviation airport with more that 80,000 arrivals and departures every year.   GMU is convenient to all of Greenville's premier destinations. The Bi-Lo Center, the Peace Center, and the vibrant downtown area are only a five-minute drive away. Shopping malls, hotels, and restaurants are located just a few blocks from GMU. The Carolina First Center (formerly Palmetto Expo Center) and The Phoenix-Greenville's Inn are located right next door, within walking distance of the airport.

The Greenville Transit Authority traverses 19 different routes, so if there's a place you have to be, it's likely the bus service can get you there. Greyhous Bus Lines also has a base of operations in the city. A limousine service offers transportation to and from the airports (in addition to GSIA and GMU, Spartanburg has its own downtown airport). In addition, larger parties can hire a limo-coach and ride in leather-interior style and wet-bar comfort.

Located close to Interstate 85, Greenville makes travel to and from Atlanta and Charlotte quite convenient. Its proximity to Interstate 26, near Spartanburg, connects it with travel to and from the Midwest. 

Greenville's Amtrak station is located on Washington Street and its run includes New Orleans, Atlanta, Washington DC, Philadelphia, Charlotte, and New York City. Car rental in town includes National, Thrifty, and Avis. 

Plans are in the works for a future rail system to link inner city and suburban destinations, office complexes, and shopping. Also in the planning stages is Greenville's participation in a high-speed rail system that will run from Washington, DC to Birmingham, Alabama.