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Day trip options from Myrtle Beach are plentiful. The quaint small towns are lovely and the attractions vary from kayaking to visiting history museums, reptile zoos, or exquisite plantations and gardens.
To the South are the Hobcaw Barony Discovery Center and historic port town of Georgetown on the Sampit River. You can schedule a riverboat trip to see the plantations along the Great Pee Dee and Waccamaw Rivers.
Further South, there's the charming village of McClellanville and just a bit further, a town called Awendaw; take the Bulls Island Ferry over to Bulls Island, part of the Cape Romain National Wildlife Refuge. The ferry ride itself is fun - you will see birds and maybe dolphins. Once there, go shelling along the beach or just walk around to see all the alligators, birds and other wildlife. There is nothing on the island but one bathroom and some picnic tables, so bring everything you need, food, water, sunscreen, etc.
Heading inland, the town of Mullins has the SC Tobacco Museum and several traditional "meat and 3" restaurants such as Webster's. Marion County has The Grove, the Inn on Harlee (a bed and breakfast in a mansion) and the Marion County Museum.
Keep going on Hwy 501 to Florence to hit two really decent antiques malls. On East Palmetto there's Thieves Market. It's in a spacious former garage complex. Vendors rent spaces to sell their antiques and 2nd hand furniture and collectibles. Prices vary, but the proprietor will assist and advise. The other is Palmetto Peddlers, a huge antiques mall in a former factory out on the west side of the city at 2295 W. Hoffmeyer Rd. Same set-up, just newer and much larger. It's so popular they have a waiting list for spaces to new vendors already, and they have thousands of square feet of space. Eat lunch at Red Bone Alley, a locally owned and independent restaurant with inspired cuisine. It's reviewed on TripAdvisor. Florence is a mere 45 minute drive inland from the Grand Strand, so it's a good diversion when the weather doesn't cooperate. Scarlett's antiques in Darlington is also a favorite.
There are several outfitters who can organize kayak trips on the various rivers close to Myrtle Beach.
Darlington, Hartsville, Dillon, Latta, Bennettsville, Bishopville, and Lake City all have pretty downtowns, good restaurants, and distinctive small town attractions. In these inland communities, there
are lots of antique stores, quaint museums, military history sites,
good restaurants and bakeries, and beautiful woodland gardens.