Cross the Ponte S. Trinita then run along the river and up to Piazza Michelangelo. Make a right out of the hotel- another right at the corner onto Via Porta Rossa to Piazza Trinita and go left onto Via de Tornabuoni toward the river- cross the Ponte s Trinita and go left along the water. Get a map from the front desk of the hotel to see which streets lead up to the Piazza- it's hilly, but less congested than the other side of the river and the view of the city from the top at the Piazza Michelangelo shouldn't be missed. Enjoy!!
Same as your previous replies, but be careful. Many of the streets are made with cobblestones and it's easy to twist an ankle. Run early in the morning before the crowds come out. They can be too thick to run around later in the morning. Good luck and enjoy!
Streets, plazas, available for your run. Turn left from the hotel and you will have many opportunities for interesting runs/city adventures.
Get an answer from Golden Tower Hotel & Spa staff and past guests.