The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis on I-64 and is near several local attractions and businesses, making it perfect for travelers of any kind. Our O'Fallon, MO hotel is conveniently located near major companies such as Citi Corp., General Motors, Mastercard, APC Nordyne, Missouri Research Park and Progress West Hospital. Leisure travelers in O'Fallon, MO can enjoy everything the area has to offer, including historic St. Charles, Six Flags Over Mid-America and the Augusta vineyards. The St. Louis Arch, Anheuser-Busch, Laclede's Landing and the stadiums of the Cardinals and Blues are just a short drive into St. Louis. During your stay at our pet friendly O'Fallon, Missouri hotel be sure to take advantage of our choice amenities, including a heated, indoor pool, a fitness center and the free Express Start hot breakfast featuring our Cinnabon cinnamon rolls. Check out our great O'Fallon hotel deals and book your stay today.