The historic quarter of Colonia del Sacramento, founded in 1680, evokes old Lisbon with its Portuguese-influenced architecture and winding streets. The area, located in southwestern Uruguay on the Rio de la Plata, was named a UNESCO World Heritage site in 1995. It's an easy day trip by ferry from Buenos Aires, making the beaches a popular Argentinean escape. Major sights include Iglesia Matriz, the country's oldest church, the Municipal Museum and a 17th-century port jutting into the river.

Santiago is one of those metropolitan joys where the more you look, the more you find. Funky cafes and dance clubs dot Bellavista, Forest Park art collections range from pre-Columbian to contemporary, and architecture runs the gamut from the 16th-century San Francisco Church to mirrored office towers. Shop with the locals at Mall Panora¡mico and give your palate meals to remember with hearty Chilean fare.

Vibrant and packed with Victorian mansions, Costa Rica's rowdy, bustling capital was built on the profits of the coffee trade and working "golden bean" plantations still surround the city. Try freshly roasted local beans at Mercado Central. For shinier gold, visit the Museo del Oro. Many renovated landmarks now house stylish hotels. Usually viewed as a hub, rather than a destination, nightlife is concentrated in Spanish village-inspired El Pueblo. Don't miss the elegant 1897 National Theater.

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

A city trapped in time, Havana captures the imagination like no other. Faded glamour meets careful colonial-era reconstruction with a backdrop of irresistible colour. Walk El Malecón, the walkway bordering the ocean; visit Old Havana and the Catedral de San Cristóbal; and listen for salsa music, open-air bazaars and parties that last all night.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Cape Town glistens at the southern toe of the African continent. Tourist brochure-views at Blaauwberg Beach and Kirstenbosch National Botanical Gardens are within easy driving distance of "The Mother City." The Cape of Good Hope Nature Reserve provides sweeping sea vistas, hiking trails and wildlife encounters. On a more somber note, travellers can visit Robben Island, the prison where Nelson Mandela was held for 27 years.

Key West has great nightlife—and a perfect cover story for someone who wants to enjoy it. A Hemingway fan simply must toss back a few at their hero’s favourite bar! You’re not reliving Spring Break, you’re immersing yourself in great American literature. Yeah. That’s the ticket.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savour fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Stretched along the Atlantic Ocean, Ghana's most populous city boasts glittering beaches, monumental buildings, museums, libraries, galleries, traditional markets and lively nightlife. Accra's architecture reflects its colonial history, with 17th century castles standing alongside modern skyscrapers. A veritable melting pot of cultures, the city's central financial and shopping districts contrast sharply with the less affluent residential areas surrounding the urban core.