We noticed that you're using an unsupported browser. The TripAdvisor website may not display properly.We support the following browsers:
Windows: Internet Explorer, Mozilla Firefox, Google Chrome. Mac: Safari.

Rx Restaurant and Bar

421 Castle St, Wilmington, NC 28401-5141
+1 910-399-3080
Map updates are paused. Zoom in to see updated info.
Reset zoom
Updating Map...
  • Excellent69%
  • Very good22%
  • Average7%
  • Poor1%
  • Terrible1%
Travellers talk about
“brunch” (25 reviews)
“pig ears” (20 reviews)
“duck” (22 reviews)
Open Now
17:00 - 21:00 Hours
American, Vegetarian Friendly, Vegan Options, Gluten Free Options
££ - £££
421 Castle St, Wilmington, NC 28401-5141
All Details
Write a ReviewReviews (252)
Traveller rating
Traveller type
Time of year

1 - 10 of 251 reviews

Reviewed yesterday via mobile

Amazing food with an inspiring menu. Make this a stop if your visiting Wilmington NC. Service was equally on par.

Thank lweilerdapkus59
Reviewed 1 week ago

We went to RX last week, Sept 27, 2018 for a birthday and the staff was super accommodating! They took the time to customize the menu for our guest's birthday. Food was awesome and atmosphere really nice. We highly recommend this stop in Wilmington NC!

Thank Tami C
Reviewed 27 August 2018 via mobile

Four of us dined early on a Friday evening. It was a great experience. Service was exceptional and professional. Our waiter knew the menu, answered all our questions and we never felt rushed. We had two appetizers, a fried veggie plate and a cheese plate...More

Thank John M
Reviewed 25 August 2018

My only ding with Rx is the noise level. When the restaurant fills up conversation becomes difficult and it can even be difficult to understand staff. The food is amazing, the service is excellent, the libations are noteworthy. They charge a reasonable corkage fee if...More

Thank Kit C
Reviewed 25 August 2018 via mobile

This was some of the best food we have ever tasted. Both delicious and creative. The area is not the nicest and you need to understand that RX is for a drug store as the only way to find it is looking for the Drug...More

Thank Lbmolloy3
Reviewed 12 August 2018 via mobile

This was a real treat. The restaurant is clean, tastefully designed and larger than expected. They take reservations which is a plus. The service is excellent. The food was hot, well presented and delicious. This is a farm to table restaurant with high quality ingredients....More

Thank Diana D
Reviewed 29 July 2018

I had the flat iron steak and it was delicious. My husband had the pork and it was okay. The portions are reasonably sized (I prefer a reasonable portion but some would say that it was small). The prices are $$$. The restaurant was cute...we...More

Thank LadyFairfax
Reviewed 13 July 2018

Wilmington is overflowing with good, local places to eat. RX restaurant is among them. It's got pretty cool decor, but the food is awesome farm to table southern inspired cuisine. The ham and pimento cheese platter is a great appetizer. The shrimp and grits and...More

Thank Adam T
Reviewed 10 July 2018 via mobile

Excellent choice in flavors and good food. For once in a restaurant I had great balanced shrimp and grits. So much to choose from and enjoy

Thank chocolatezeus
Reviewed 9 July 2018

We are long time Wilmingtonians, with a daughter in the big city. While we are generally much more casual diners, when n NYC, we usually try a wide variety of good restaurants. Rx truly reminded me of several of these, but without over-crowded spaces, tables...More

Thank Fotoefek
Nearby HotelsSee all 45 hotels in Wilmington
The Wilmingtonian
237 reviews
.47 miles away
Riverview Suites
185 reviews
.75 miles away
Courtyard Wilmington Downtown/Historic District
402 reviews
.79 miles away
Hampton Inn Wilmington Downtown
213 reviews
.79 miles away
Nearby Restaurants
Little Dipper
256 reviews
.47 miles away
Le Catalan
250 reviews
.48 miles away
Jester's Cafe
130 reviews
.11 miles away
Nearby Attractions
Downtown Wilmington
602 reviews
.50 miles away
Burgwin-Wright House and Gardens
90 reviews
.51 miles away
Zebulon Latimer House
59 reviews
.39 miles away
Waterline Brewing Company
33 reviews
.38 miles away
Ask a question
Questions & Answers
Cynthia F
18 January 2015|
Response from Betsy V | Reviewed this property |
A wicked good pork belly, grits and egg dish...a twisted Monte Cristo... Eggs Benedict...buscuits and housemade peach jam, lots more...
Cynthia F
18 January 2015|
Response from Betsy V | Reviewed this property |
Small compared to other varieties/areas I have sampled. But the minionette on the raw ones is inspired....
Improve this listing

Restaurant Details

Rating summary
  • Food
  • Value
Average prices
US$30 - US$30
Dinner, Brunch, Lunch, After-hours
Restaurant features
Reservations, Seating, Waitstaff, Wheelchair Accessible, Serves Alcohol, Full Bar
Dining Style
Casual Elegant
Good for
Romantic, Bar Scene, Child-friendly, Business meetings, Local cuisine, Special Occasion Dining
Open Hours
10:00 - 14:00
17:00 - 21:00
17:00 - 21:00
17:00 - 21:00
17:00 - 21:00
17:00 - 21:00
Location and Contact Information
  • Address: 421 Castle St, Wilmington, NC 28401-5141
  • Location: United States  >  North Carolina (NC)  >  North Carolina Coast  >  Wilmington
  • Phone Number: +1 910-399-3080
  • E-mail
Located in the old Hall's Drugstore on 5th and Castle
Is This Your TripAdvisor Listing?
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more. Claim Your Listing