What dates and times are we talking about herr?
In my experience there is no single best way - you could book a series on one way tickets with the likes of South West avoiding checked baggage fees.
Alternatively you could book an open jaw (Minn to SF, San Diego to Minn) with a one way from SF to San Diego or a single multi city ticket covering all the flights.
It all comes down to researching your airline options and deciding what works best for you - check matrix to see options but also check South West who don't appear on matrix.
There is no best way. You should check both a single multi city ticket and one ways using different airlines. No way to know which is cheapest without checking
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