Are you planning to do this during this summer?
The route usually recommended as the most scenic is I-5 to Roseburg, the North Umpqua River Scenic Hwy (138) to Diamond Lake and the north entrance to Crater Lake. When you say "spend the night" what did you have in mind. Unless you already have reservations at the Crater Lake Lodge, you'll need to have a Plan B in mind. If you want the quickest way back to Tacoma, you'll go out the south entrance to I-5.
Let us know when you're going and what sort of lodging you're expecting.
Agree best route 138, Suggest you spend night at Diamond Lake Resort. drive CL loop, then head north on 58 to I-5 at Eugene.
Do I think a good idea?? No
You say Charlotte NC. Does not seem like 2 day trip to CL best thing you could do to see NW if your first trip
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