I just checked American and United websites and saw no advisories. If this system goes close to the current projected path, airlines MAY modify/cancel flights into the area.
If that happens, they may also allow a no cost change to your current trip. Available seats on earlier/later flights may be limited so those who make a change sooner (if appropriate) may stand a better chance of being accommodated.
This system may alter the departure plans of some already in the area.
Consult your airline often in the coming days, know your options, have contact info, etc.
I am not suggesting that anyone change their current travel plans. Stayed informed of the status of this system, your airline policies and make your decision accordingly