My husband and I just spent 10 days on Isla (2.28 - 3.10. It was my third trip, but his first, and he fell under the island's spell as totally as I have.
We stayed at Villa Makax on Sac Bajo. Though it is a few miles out of town, the quiet mornings and wonderful sunsets more than make up for the cost of the golf cart we rented (Isla Golf Carts on Juarez, $47 per day).
Our half cottage had a small kitchen and opened up to a great little porch and a palapas right next to the beach. It was pure heaven. The mornings were quiet, but catamarans came in at the adjacent properties some days. They were gone by 4 PM, so the evenings were mostly quiet as well.
We usually ate breakfast in town (Alexia y Geovanny and Manana were our favorites, then picked up a roasted chicken at La Mexicana roticerie (Guerrero) for lunch or sometimes dinner. We also had amazing chicken and ribs from the rib guy (Sunday mornings on Matamoros), and some incredible enchilada's at La Lomita (Juarez). My husband also fell in love with the flan sold by a wonderful woman outside the big grocery store. She was there on weekend nights.
As I said in another post, Isla is a safe place for a vacation. The locals are warm and generous. The police made patrols at night and other than a few drunks, they just kept an eye on things.