I have always found the Peace Bridge to be the best, they always seem to have many booths open and move fairly quickly. Queeston-Lewiston would be the most convenient, but tends to be the busiest, although they have just opened an addition 2 inspection booths on the Canadian side, which will help. Rainbow Bridge will likely be busy with tourist traffic.
When you get close to Buffalo, call the bridge traffic hotline, 1-800-715-6722, (or watch for the digital signs on the highway) to get current conditions and then make your decision from that.
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