This question has been prompted by an answer on another forum..
"If your nightly stops is set as is, I would head north first... get as much driving out that first day as possible since you can't get into a hotel/B&B right away -- plus if you force yourself to stay up, I think you'll adjust to the time change much easier. Why Donegal? Don't get me wrong, I like it and have visited several times but it is a lot of driving for just a few nights. If you have specific reasons then that makes sense but if someone told you to do it... perhaps you might want to skip it this trip.
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Personally if someone is coming in on a Red Eye I would say no more than 200 motorway miles or 100 general road miles. Even those distances would be pushing it!!