it depends on how comfortable you are ordering airline tickets on line - Last year we did this on the Air France web site from Boston to barcelona (Layover in Paris 2hrs)-toulouse to Paris and then back yo USA on line; you would then need to do your hotels in each area which also requires web searching and booking either though expedia.com booking.com or the like - or directly with the hotel. If you have some experience with travel and Europe, you would probably be able to do it; otherwise you would be far better off with a good travel agency - they can put any kind of independent trip together for you, or you could join a tour that they have put together and travel with a group
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