I live in south west Scotland and would appreciate any advice on the best route/form of transport etc to visit Bayreuth.
Closest airport to Bayreuth is Nuremberg Airport (NUE).
E.g. flybe.com fliest from Glasgow to Frankfurt.
Easyjet flies from Glasgow to Berlin-Schönefeld (SXF). That's however 5 hours from Bayreuth.
You can check the travel times to Bayreuth with the DB timetable
Destination: Bayreuth Hbf