We are 2 couples leaving for Italy at the end of May and this is our first trip there. On a high level, our itinerary is to visit Rome - Tuscany region (not exactly sure which region or towns yet) - Florence - Venice. We arrive in Rome and are ok to stay 1 or 2 nights there but would love to get an appt. or villa anywhere in the Tuscany region for 1 week that would enable us to travel by car or train within Tuscany (including Florence). I am undecided if I should focus on finding something in the North, South, East, West or central region. I do know that we want to see Siena and the Chianti region. Otherwise I am open .... any thoughts ?