I'm trying to find the best way by bus to go to the colosseum, termini station and piazza di spagna by bus from our hotel in the Vatican, Spring House Hotel.thanks in advance
I don't use the buses so I can't help with that but your hotel is right between two metro stops, cipro and ottaviano. You can get on either of these and get off at the stops you mention. You will have to change trains at the termini station to go to the colosseum but that is very easy to do. The trip from cipro to the spanish steps should take about 6 minutes and then another 4 to get to the termini. It is very quick.
If you, like me, prefer to take buses rather than the metro (and get more of a feel for where you are) then this is the site for you. There is a route planner which you can access in English - just put the address of your hotel in and your destination and it will give you a map and the number of the bus or buses you must take. There is an option where you can say "no underground" and it will give you bus routes only.
bus #81 takes you almost every where, to the colosseum as well as to the spanish steps area. The starting ride is in Risorgimento Square (piazza risorgimento). Take a look to the route:
You can find the bus tickets at the newstand in the square!
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