We are excited to visit Rome in late April for two weeks and also want to visit Prague. So we will stay in Rome for 4-5 days then we thought about renting a car and driving to Prague over 2 days(maybe staying in Venice?), staying 3-4 days and driving back over 2 days. We just thought this might be an interesting adventure and allow us to see more of the country than a plane or rail. Also allow us less problems with luggage. Let me know if we are nuts and/or this is feasible. :-) We are mid 30's and a little adventurous and not trying to save $$, but just experience more of the land. Thank you for any advise...its our 1st trip to Europe!