You can easily walk and enjoy the museums if you are in good health. It should take around 50 minutes. I would go for the earliest entry available and walk across to the Vatican in the early morning. Rome is really lovely at this time of day.
Once you reach the museums, you will find that you have plenty of opportunities to sit and rest while you view the collections. There are also places to grab something to eat and drink while you are inside. There is no need to feel exhausted at all.
If you have health issues that prevent you from walking then just grab a metro from the Termini. Do not catch the 64 bus! It is worked daily by pickpockets and professional hustlers. The metro is the best way to go.
Have fun and enjoy your visit.
As stated by penny, it's at least an hour walk to get there from the termini area. I would suggest taking the metro and saving your strength for visiting the museums and basilica. If you feel up to it just walk back to the hotel from there.
Great! Thank you so much!
Metro seems a logical choice, as mentioned above. Important to save your leg strength. Have good walking shoes either way.
There are several buses, the that go to the Vatican area from Termini station, and that will involve less walking than the metro. Some will immediately say that there's a great risk of having your pocket picked on these buses, but lately I've been reading of incidents on the metro a lot more than on the buses, In fact, you have to be vigilant in any crowded place, even in St. Peter's Square, which is a favorite hunting ground of pickpockets.
The number 64 bus and the number 40 bus leave from Termini station and go to the Vatican. The number 62 bus runs along Via XX Settembre, a few streets over from the station, and goes to the Vatican. I really prefer using the buses rather than the metro, because it allows you to see the city. Just keep your possessions well protected and your wits about you. I've been spending lots of time in Rome for almost twenty years, and haven't ever had anything stolen.
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