I've been to Rome a couple of times before. I stayed near Trevi once, near P. Barberini another time. I'll be there again next June before a cruise. I am looking at hotels, and I see some possibilities in the Vatican area (on that side of river) or Trastavere.
What would it be like to stay in the Vatican area? Is it easy to get back/forth from the main tourist sites (Spanish Steps, Trevi, etc)? I'm traveling with some friends who have never been to Rome, so I want to be sure that they'll have a good experience.