I know that there is a Europcar office in the town of Como. There may be others. It is possible that there are one or two rental companies in the town of Lecco but I think that como is your best bet.
Remember - there are hefty fees to drop a car off in second coutry from where you pick it up. If you are getting your rental in Switzerland, then you might want to drop it off in Lugano and bus back.
I will be picking up a car from Malpensa airport.
There's also an Avis in Como, which I would agree is probably your best bet for a convenient drop-off point. Both the Europcar & Avis offices are within 200 meters of each other and easy walking distance (if you're not overburdened with luggage -- there's a little bit of a hill) of the San Giovanni train station in Como.
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