No, that seems to be your best route. Take the #2 to Piazzale Roma, then the DM. But are you going to go straight to Murano and bypass Venice itself? Murano is so much of a tourist trap - it is glass shop after glass shop and supposedly much of it is really not from Murano any more. There is so much more to see and do on Venice.
I am firmly of the opinion that visting Murano for the sake of the glass factories is a waste of time and effort but there are good things on the island - the Glass Museum, Santi Maria e Donato, S. Pietro Martire for the paintings and some good restaurants as well.
It is the Museum that the poster is interested in it seems,
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