It would be best to go to the "islands" stop on the Fondamenta Nuove (although intended for a different purpose, see map on here: http://www.mapmyrun.com/s/routes/view/run-jog-map/venice/21455076), which is only a short walk beyond S. Marco, and take line 12.
See "lagoon routes" on here europeforvisitors.com/venice/articles/vapore…
Also refer to the vaporetto route map at hellovenezia.com/images/stories/navigazio/Ma…
YOu could but its a long ride, you would be quicker to either walk up to the Fondamente Nove or even vaporetto to the Ca Doro and walk through
If we plan to visit bruano first, So line 12, what line and direction do I go on for murano?
Which island is most pretty to see at sunset?
Back to Murano you catch 12, the boats do have the destination on them , the stop will clearly tell you which direction,
I am actually responding to one of your posts (can't find it this morning)I read yesterday in response to a question about a couple (one of them used a walking stick) and the Rialto Bridge. I have been looking at the ACTV Network Map for Vaporetto. We will be arriving at railway station. If we want to visit Rialto Bridge and have dinner at Osteria Barababao, do you recommend we get off at Rialto Mercato, or Rialto, on the 1, 2, N, or A? What I'm really not sure about is getting off on the wrong side of the canal. I don't think I'm reading the map correctly because I can't tell If I should be riding in a certain direction. Our time there is limited so the order (bridge-dinner; dinner-bridge) doesn't matter...we will follow your suggestion. I enjoy reading your wisdom-filled posts!