Santorini is one of the most beautifful and safe island of the world no problems at all if you walk around the streets either in night.
Which is your choise for the hotel taht you choose ?
Night life is excellant you may go to Koo, Enigma club and to Tango wich is on the cliff , for Greek live music try the 50-50 is the #1 at the moment for nice Greek live music.
I only went to Murphey's Bar, it has a lot of Americans and Brits but be aware that in Fira some of the bars charge a lot. When in Murhey's a few weeks ago these four people were drinking and when the tab came they all let out a "###". At 7.5 euros for a beer on tap it can add up fast. They do have bottled beer specials aat night for around 3 euros.
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