you would need to review the itineraries to decide which is "nicer".
Many people prefer an itinerary that sails on the east of Vancouver Island as it is a more scenic route, as opposed to the west side which isn't as scenic and be rougher. Vancouver departures typically do the east side of the island.
If you look under the Top Questions, you'll find an informative article about Alaska cruises.
Also if you depart from Seattle, one of your ports is Victoria. As I'm sure you're aware, that's not in Alaska....(the ship has to include a foreign port).
I vote for Vancouver. You have the first full day sailing in very scenic territory. From Seattle you will be out in the open ocean with a greater chance of rougher seas on both your first and last days. If you are looking at round trip cruises, the HAL cruise that goes to both Glacier Bay and Tracy Arm is my favorite itinerary. If you are looking at a one-way cruise my favorite is the Princess southbound that includes Glacier Bay and Hubbard Glacier. These are both scenic jackpot cruises in my mind. If you are more interested in ports, then you need to look at other itineraries.
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