Is not a problem to catch a bus from granada, but not from san juan del sur, you have to go to rivas to catch tica bus.
Leaves granada at 07:00am and pass at rivas at 08:20am arrives at San jose at 04:00pm and then leaves from san jose to panama city at 11:00pm arrives at panama city at 04:30pm.
If you want to catch the 11pm bus to panama they recomend you to catch the first bus to Costa Rica in case of something that happen on the road or on the border, but can be done, the other thing is that there is a Transnica bus leaving a 10am from granada and you arrived abot 8pm at costa rica enough time to catch the11pm tica bus to panama
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