You need at least a day at Pamukkale, and it takes approx 8 hours by overnight bus. You could leave at a night bus (2100) and arrive to Pamukkale at 0600, then leave again that night, I think the last bus leaves at 2330. I use Metro Turizm bus co and they drive you to Denizili and Metro guys pick you up and drive you 20-25 minutes to Pamukkale center, it works out great.
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