This is probably a bit out of date now, but we did this route in October 2011. It is safe enough as the first leg you are just passing through the jungle overnight and everyone is asleep on the bus, there was one toilet/snack break half way through at a shack in the middle of nowhere! There a few a good street vendors around the bus station in Boa Vista to eat while you wait for the transfers.
We picked up a Romanian travelling on his own for the final leg and now have a new friend so it was definitely safe enough for me!
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