I can't really tell you about things to on your route, hopefully someone else has info on that. I would avoid Atlanta between 2-6 on a Friday due to the traffic.
Sorry for the slow reply!
>driving between Savannah and Birmingham.
There are two main routes that make sense for that trip: I-16 to I-75 near Macon, GA to Atlanta to I-20 to Birmingham. That is the way I would go. As long as you avoid the rush hour times (~7-9 am and 4-7 pm) it's not that bad.
As far as "must sees", what are you interested in? Savannah to Macon is a pretty desolate stretch, I don't know of anything to see. Macon has some lovely old homes and the Georgia Music Hall of Fame; I can't think of anything else I'd want to see/do there. Just north of Macon is Juliette, GA where the movie "Fried Green Tomatoes" was filmed. Atlanta of course has LOTS of attractions, the High Museum of Art and the Varsity restaurant being my favorites. Between Atlanta and Birmingham is another long stretch of pine trees. You can always stop and tour the Talladega Superspeedway; the natural history museum in Anniston is interesting too. Mt. Cheah (sp?) is Alabama's highest point and has a nice restaurant at the top; you can drive right up.
Like Atlanta, Birmingham has lots of sights; give us some ideas what you like and we can be a bit more specific :-)
For sure avoid Atlanta. I am not too sure about alternate routes, but if it is not too far out of the way you may want to consider traveling through Eufala, it is a really neat little town.
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