What is your budget per night?
Hollywood to Santa Monica is two buses. Disneyland from Hollywood is either a one subway ride and one long bus ride, or a subway ride, a train ride, and then a 2nd bus ride. Or, you can go directly via tour bus (www.starlinetours.com) which will cost more money. Some of these options may not let you reach Disneyland until after it opens, and depending on Disneyland's hours that day, may require you to leave to get back to Hollywood before Disney closes - so as you can see, with your own car, you can maximize your day at Disney - without one, it may not be possible.
Downtown LA has basically the same transportation options to Disneyland as Hollywood does, but the trip is a little shorter. There is an express bus from downtown LA to Santa Monica.
Note - Hollywood and downtown LA are linked via subway so its easy to transit between the two.Edited: 28 May 2013, 18:34
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