Many people like to stay in the middle keys such as Islamorada or Marathon. There are resort type places such as PostCard Inn, Cheeca Lodge or Tranquility Bay and there are other smaller hotels. You can easily make day trips to the rest of the keys from either location. Others may take a couple nights in Key West and a couple nights in the upper keys.
Some idea of travel dates and budget, along with likes/dislikes would help give us an idea of what to base our suggestions on....
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