What are your likes? Dislikes? Budget? Time of year? A rental car offers the most flexibility.
I'd suggest the Greyline tour too. They'll take you to the places you 'll probably want to go, without the hassle of driving, navigating, and finding parking. It is doable as a day trip, but figure it's 8 to 10 hours in the car for 8 to 10 hours on the ground. Me personally, I'd do it in a second. I love Miami.
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