You wouldn't be able to avoid mountains entirely. And you could plot a route that would have you driving through mountains for many hours on end. So, yes.
If you did it by the fastest route, though, most of the mountains you'd see would be in western Massachusetts (the Berkshires), which is a beautiful area, but not comparable to the White Mountains in terms of the height and ruggedness of the peaks.
Thank you for your response. We love the Smoky Mountains if that is what the mountains are like. On the other hand, we drove the milliion dollar highway through the Rockies and were terrified. So it sounds like we will do okay if we plan our route wisely. :)
Edit: sorry NE Weaver...somehow I missed your post and mine repeats a lot of what you said. At least we are in agreement :)
Are you planning to take I-90 across NY?
If that is the case, just North of Albany is Troy, NY (where RPI is). Jump on Route 7 heading East towards Bennington, VT. In Bennington, Route 7 becomes Route 9 which can be a wonderful drive through the southern part of the Green Mountain National Forest all the way to the New Hampshire border.
In New Hampshire, continue East on Route 9 through Keene (becomes Route 101) through the southern hills of the Monadnock region (and past Mt Monadnock, the most climbed mountain in North America).
There are several routes you could take from the Monadnock region to Durham:
-Route 101 out to the coast and up to Durham
-Route 202 to Hillsborough, Route 9 to Concord, and Route 4 to Durham
-(you could take Route 9 all the way from Bennington, VT through Brattleboro VT and Keene NH to Concord but you would miss most of the Monadnock region)
NH's White Mountains and Lakes Regions are definitely worth seeing but neither would really be on your way to Durham if you are taking I-90 across NY. If you were driving across Canada and then down into VT/NH, then everything changes.Edited: 16 March 2011, 13:56
If the goal is a pretty route that takes longer, then LRBB's suggestion is great. But, according to mapquest the quickest route is the Mass Pike which would have no mountains. bottom line is that you won't see anything like the Rockies unless you make a wrong turn and end up climbing mount washington.