What is the best way to travel from the airport in Leon to Lagos to Moreno on a weekday around noon.
You didn't define "best".
I don't know.
Cab to Leon bus station and then second-class bus to Lagos de Moreno. There are no online schedules for the latter but it's not far and there will be plenty of buses - you will just have to ask to find out where they leave from.
Take a cab bus terminal and take the Plus bus is first class they leave regularly not a lot