Hi PennyAA -
I'm assuming by "direct" you mean non-stop? The airports in Philadelphia and Newark, NJ are about the same distance from Wilkes-Barre and both offer non-stop flights to Las Vegas. It's been years since I've been to Newark, but I flew out of Philadelphia recently and it's a really easy drive from here.
I usually fly out of Philly when given a choice b/c I prefer non-stop flights where possible. Parking is less expensive in Philly than Newark and I feel the drive to Philly is an easier one so I guess I am partial to the Philly airport.
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