During my wanderings I happened upon SoHo and fell in love. There was every high end label you'd want, plus some little boutiques with affordable prices. Some of the main flagship stores are located there, for example Kate Spade, and the whole area just buzzed with a fun vibe.
I went twice during my trip and there were street vendors each time selling jewelry. I bought a few pieces that were inexpensive and 100% like nothing I've ever seen in a store. What a great memory!
If you're going to go, the main areas are the square in between Broadway, Houston, Bowery and Broome. Be sure to check out the little side alleys with the charming cobblestone streets such as Mulberry and Crosby. Walk up and down Spring, Prince and Broome.
Such a great area!