We have visited Alsace each of the last 3 years and enjoy the friendly people and the ambiance of the vineyards and small villages dotting the landscape from Mulhouse to Strasbourg. We have drove the entire length of the Alsace wine route and visited most of the villages where good eating, shopping and very friendly people. Colmar is our favorite to stay, where a familiar chain of hotels that are found in most of western Europe and reservations are easy to make in advance over the internet or from one of there hotels anywhere in France. The best way to see Alsace is via car if you drive because it allows time for stopping by the villages and having a good meal, talk to friendly folks in the stores and just plain relax with no hussel or bussel. If you need to get to a large store there is one just north of Colmar's airport in Hussein (sp), probably the largest in North-Eastern France.
For those who like wine, Alsace has great wine and we especially like the Pinot Blanc, Riesling and Pinot Gris but it is the Gewurztraminer that is there famous along with these. The food here is great combination of both the French and German culture. And if you are up in the hills you can see why the cultures are so intermixed with the Rhine river so close by.
Lastly, our visits have all been in September and early October and this has given us the perfect temperature and daylight hours.