The hotel is conveniently located and relatively inexpensive, the rooms are quiet and clean (though extremely small), the breakfasts are excellent, and we found the staff to be polite and friendly.
However I could not say they were helpful. They were unable to assist with any of the problems I encountered, specifically:
1) room being too cold because of a hyperactive ventilator
2) inability to access internet
3) scrambled reception of all the English-language TV stations (except Russia Today)
The other main drawback was the smallness of the rooms. Ours was too tiny to contain any drawers or storage space, aside from a narrow closet for hanging a couple of jackets. And the bathroom was too tiny to contain anything other than a toliet and shower, separated by a curtain. (The sink and mirror were in the bedroom. This actually gets quite annoying.)
In addition, I wasn't happy with the way our reservation was handled. A few hours before our arrival (while on the Eurostar from London) I received an email from the hotel saying that our booking was not confirmed and would not be held past 6pm. This contradicted a confirmation email I had received several days earlier from Hotels.com. (This email had also said I would be charged for cancellation less than 48 hours in advance, which seems a little unfair given that the hotel waited until a few hours before arrival to say they would not hold my booking!) The explanation was simply that this was their policy.
If I ever return to Lyon, I will probably try the Ibis hotel next door, rather than returning to the Central Perrache.