The Vatican is a must see for any one in Rome. We visited on a day the pope was giving a speech to children so the area was packed. You couldn't move in certain parts. We bought a skip the line ticket which was well worth the extra money. Be sure to go to St Peter's Basillica. Our ticket allowed us to skip the queue but on exiting the Vatican museum we were ushered a different direction and we missed St Peter's Basillica. Bring a cover for your shoulders and arms as you cannot enter the Sistine chapel with out. Expect crowds through out your tour of the museums and a lot of walking.