Everyone wants to see Michelangelo great works, but to do so be prepared to be pushed through never ending corridors to get to your final destination. The whole experience is smells so much of a "get-em, push-em out" approach to crowd management that it is really hard to get an appreciation of the art works. Whatever you do try to avoid the coach loads of tourist, try picking a time when they will be minimal, which is hard to do.
It's one of those things first timers to Rome have to do, so be prepared for a bone crushing experience.
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