The cathedral is beautiful and worth the stop. To get to the top of the duomo you have to buy a 10€ ticket - there are automated machines so do not waste your time in line there! Bathrooms in the ticket center are 1€ and very clean. Get in line EARLY. Send someone to buy tickets while someone holds your spot in line. We waited in line for over three hours and then had to leave because we had another appointment to make. The tickets are good for 6 days and I am assuming it is to make up for the lack efficiency in line. If you have a Firenze pass you have a priority entry - which slows the main entry. Bottom line you will waste nearly half a day in line for some beautiful views - just prepare yourself for a lot of standing.
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