We decided to take route 41 - Tamiami trail because it looked scenic and we were not disappointed. We saw gators in the wild - so much better than seeing them in captivity, there are lots of places to stop - great information centres, an Indian village ( we did not stop there though) and a photographic gallery which was very interesting and had some fantastic photographs taken using a box camera which you can see in the gallery too. If you have the time, take the Tamiami trail!
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