The Swissotel Hotel in Quito is a very well managed and friendly establishment. We spent one night here as part of a package to the Galapagos. Beds were great. Standard room large with an amazing view (even on a lower floor) to the beautiful mountains and city. We received a welcome drink upon arrival and were able to store one of our bags in their storage area before we set out for our Galapagos cruise. With no extra charge, even though we weren't returning to that same hotel after the cruise. Finally, breakfast was outstanding. Overall, after arriving from a 19-hour flight, this Swissotel fit the bill.
I would suggest that if you are staying for longer than a night or two, base yourselves in Quito's historic center. Very colorful, seemed safe and much more interesting than what you get in the newer neighborhoods. On our way back from the cruise, we spent two nights in the Historic Center and well worth it.More