I recently needed to stay in San Fran for business and the St. Regis is proximate to my Firm's office. The overall location is fine as well. The Muni station was just a couple of blocks away and the F line just up the street. I was very pleased. Everything I needed for business purposes was available and convenient. I will set aside (well almost) my pet peeve of high end hotels charging for internet when mid-range hotels do not, but that is not unique to the St Regis. Common areas, while very modern, were nonetheless warm and inviting. Service was excellent and friendly.
My room was very comfortable and quiet. The shower is outstanding and the bathroom spacious. When I told the front desk that I was extending my stay and that my wife was joining me for the weekend, they offered to move me into an upgraded room. These folks know how to win your loyalty. Make me look good to my beloved and you get my repeat business in a heartbeat. Plus the room was so pleasant to my wife it resulted in her choosing to use the hotel spa as well.